| CatalogCode: | NB100-55881 |
| ProductName: | Caspase-12 (IN) Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase-12 (IN) |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide sequence corresponding to amino acids 100-116 (CTPSSPSESKRKVEDDE) of murine caspase 12 was used as immunogen; GenBank no. emb CAA73532.1 |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 0.5-1 ug/ml ~; IHC (paraffin): 2 ug/ml |
| Control: | Murine brain tissue lysate can be used as positive control. |
| Background: | Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | Caspase-12 (IN) |
| PackageSize: | 0.1 mg |