| CatalogCode: | NB100-55854 |
| ProductName: | PHAP Antibody |
| Product Description: | Rabbit Polyclonal anti-PHAP |
| Clonality: | Polyclonal |
| Immunogen: | Human PHAP (NT) peptide. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg Rabbit antisera. |
| Uses: | WB: 0.5-2 ug/ml |
| Control: | also: MDA-MB-231 from Santa Cruz |
| Background: | Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases, which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | PHAP (NT) |
| PackageSize: | 0.1 mg |
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