| CatalogCode: | NB100-55850 |
| ProductName: | Neurturin Antibody |
| Product Description: | Rabbit Polyclonal anti-Neurturin |
| Clonality: | Polyclonal |
| Immunogen: | Human NTN (NT) peptide. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 2-3 ug/ml |
| Background: | Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRa. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. NTN binds to and forms a complex with GFRa-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | Neurturin |
| PackageSize: | 0.1 mg |
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