| CatalogCode: | NB100-55771 |
| ProductName: | PUMA alpha Antibody |
| Product Description: | Rabbit Polyclonal anti-PUMA alpha |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was generated by immunizing rabbit with synthetic peptides of human PUMAa (NT). It will cross-react with mouse. |
| CrossReactivity: | Cross reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rabbit antisera. |
| Background: | A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) in human and mouse. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 295 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu |
| ProteinTarget: | PUMA a (NT) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Nakano K., et al. Mol Cell. 7(3):683-94 (2001). 2. Yu J., et al. Mol Cell. Vol 7,673-682 (2001). 3. Han J., et al. Proc Natl Acad Sci U S A. 98(20):11318-23 (2001) |