| CatalogCode: | NB100-55747 |
| ProductName: | DcR2 Antibody |
| Product Description: | Rabbit Polyclonal anti-DcR2 |
| Clonality: | Polyclonal |
| Immunogen: | Rabbit anti-DcR2 polyclonal antibody was raised against a peptide corresponding to amino acids 249 to 263 of human DcR2 precursor (2). |
| Specificity: | A band of approximate molecular weight 35 kD will be detected. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Affinity Purified |
| Uses: | WB: 1:1000 to 1:2000 |
| Background: | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL/R4, or TRUNDD (2). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | DcR2 |
| PackageSize: | 0.1 mg |
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