| CatalogCode: | NB100-55419 |
| ProductName: | GNRHR Antibody |
| Product Description: | Goat Polyclonal anti-GNRHR |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-QKWTQKKEKGK, representing the internal region of the human protein according to NP_000397.1; NP_001012781.1 |
| Epitope: | QKWTQKKEKGK |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 60kDa band observed in Human lysates of Peripheral Blood Mononucleocytes (calculated MW of 37.7kDa according to NP_000397.1). The observed molecular weight corresponds to earlier findings with products from other commercial sources. Recommended concentration: 0.5-1.5ug/ml. |
| Control: | Human Peripheral Blood Mononucleocyte lysate |
| Background: | This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-GNRHR antibody, anti-gonadotropin-releasing hormone receptor antibody, anti-GNRHR1 antibody, anti-GRHR antibody, anti-LHRHR antibody, anti-LRHR antibody, anti-gonadotropin-releasing hormone (type 1) receptor 1 antibody, anti-leutinizing hormone releasing horomone receptor antibody, anti-leutinizing-releasing hormone receptor antibody, anti-luliberin receptor antibody, anti-type I GnRH receptorantibody |
| ProteinTarget: | GNRHR |
| PackageSize: | 0.1 mg |
| Homology: | Human, Dog |
| GeneralRef: | Yeung CM, An BS, Cheng CK, Chow BK, Leung PC. Expression and transcriptional regulation of the GnRH receptor gene in human neuronal cells. Mol Hum Reprod. 2005 Nov;11(11):837-42. Epub 2005 Dec 19. PMID: 16364974 |
| Gene_Id: | 2798 |
| Omim_ID: | NB120-22168 |
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