| CatalogCode: | NB100-55397 |
| ProductName: | SMO Antibody |
| Product Description: | Goat Polyclonal anti-SMO |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-QSDDEPKRIKKS, representing the internal region of the human protein according to NP_005622.1 |
| Epitope: | QSDDEPKRIKKS |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:1,000. Western Blot: Approx 60kDa band observed in Human Bone Marrow lysates (calculated MW of 86.4kDa according to NP_005622.1). The observed molecular weight corresponds to findings with EB07026, a product of different design reacting to a different part of the same protein. Recommended concentration: 0.1-0.3ug/ml. |
| Control: | Human Bone Marrow lysate |
| Background: | Smoothened (SMOH), a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein (PTCH) to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. SMO expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-SMO antibody, anti-smoothened homolog (Drosophila)antibody, anti-Gx antibody, anti-SMOHantibody, anti-seven transmembrane helix receptor antibody, anti-smoothenedantibody, anti- antibody |
| ProteinTarget: | SMO |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature. 2002 Aug 22;418(6900):892-7. Erratum in: Nature 2002 Nov 28;420(6914):445. |
| NotesMain: | Other Gene IDs: 319757 (mouse); 25273 (rat); |
| Gene_Id: | 6608 |
| Omim_ID: | H00006608-A01 |
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