| CatalogCode: | NB100-55394 |
| ProductName: | NR4A1 Antibody |
| Product Description: | Goat Polyclonal anti-NR4A1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-GRLPSKPKQPPDAS, representing the internal region of the human protein according to NP_002126.2; NP_775180.1 |
| Epitope: | GRLPSKPKQPPDAS |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 60kDa band observed in Human Thyroid gland lysates (calculated MW of 64.5kDa according to NP_002126.2 and NP_775180.1). Recommended concentration: 1-3ug/ml. |
| Background: | Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-NR4A1 antibody, anti-nuclear receptor subfamily 4 antibody, anti-group A antibody, anti-member 1antibody, anti-GFRP1 antibody, anti-HMR antibody, anti-MGC9485 antibody, anti-N10 antibody, anti-NAK-1 antibody, anti-NGFIB antibody, anti-NP10 antibody, anti-NUR77 antibody, anti-TR3antibody, anti-TR3 orphan receptor antibody, anti-early response protein NAK1 antibody, anti-growth factor-inducible nuclear protein N10 antibody, anti-hormone receptor antibody, anti-orphan nuclear receptor HMR antibody, anti-steroid receptor TR3 antibody |
| ProteinTarget: | NR4A1 |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Kiss I, Oskolas H, Toth R, Bouillet P, Toth K, Fulop A, Scholtz B, Ledent C, Fesus L, Szondy Z. Adenosine A(2A )receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. Eur J Immunol. 2006 Jun;36(6):1559-71. PMID: 16673448 |
| NotesMain: | Other Gene IDs: 15370 (mouse); 79240 (rat); |
| Gene_Id: | 3164 |
| Omim_ID: | PAB0547 |
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