| CatalogCode: | | NB100-55392 |
| ProductName: | | SMO Antibody |
| Product Description: | | Goat Polyclonal anti-SMO |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide, C-NLMDTELMDADSD, representing the C Terminus of the human protein according to NP_005622.1 |
| Epitope: | | NLMDTELMDADSD |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 60kDa band observed in Human Bone Marrow lysates (calculated MW of 86.4kDa according to NP_005622.1). The observed molecular weight corresponds to findings with EB07444, a product of different design reacting to a different part of the same protein. Recommended concentration: 0.3-1ug/ml. |
| Control: | | Human Bone Marrow |
| Background: | | Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Smoothened expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-SMO antibody, anti-smoothened homolog (Drosophila)antibody, anti-HGNC:11119 antibody, anti-Gx antibody, anti-SMOHantibody, anti-seven transmembrane helix receptor antibody, anti-smoothened antibody |
| ProteinTarget: | | SMO |
| PackageSize: | | 0.1 mg |
| Homology: | | Human, Dog |
| GeneralRef: | | Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. Vertebrate Smoothened functions at the primary cilium. Nature. 2005 Aug 31; [Epub ahead of print] PMID: 16136078 |
| Gene_Id: | | 6608 |
| Omim_ID: | | H00064093-A01 |
| more information: | | company product webpage |
|