| CatalogCode: | NB100-53808 |
| ProductName: | PEBP1 Antibody |
| Product Description: | Goat Polyclonal anti-PEBP1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-DPDAPSRKDPKYRE, representing the internal region of the human protein according to NP_002558.1 |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx 21kDa band observed in Human Prostate lysates (calculated MW of 21.1kDa according to NP_002558.1). Recommended concentration: 0.01-0.03ug/ml. |
| Background: | PBP, also known as RKIP (RAF kinase inhibitor protein), binds ATP, opioids and phosphatidylethanolamine. PBP is able to regulate Aurora kinase B expression and the spindle checkpoint through interaction with the RAF1/MEK/ERK cascade. PBP is able to bind to RAF1 and MEK and competitively disrupt the interaction between these proteins. PBP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. It increases the production of choline acetyltransferase but not acetylcholinesterase. PBP has been implicated as a suppressor of metastasis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-PEBP1 antibody, anti-phosphatidylethanolamine binding protein 1 antibody, anti-HCNP antibody, anti-PBP antibody, anti-PEBP antibody, anti-RKIP antibody, anti-prostatic binding protein antibody, anti-RAF kinase inhibitor protein antibody |
| ProteinTarget: | PEBP1 / RKIP (Internal) |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W.Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.Nature. 1999 Sep 9;401(6749):173-7.PMID: 10490027 |
| Gene_Id: | 5037 |
| Gene_Symbol: | PEBP1 |
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