| CatalogCode: | NB100-53778 |
| ProductName: | UHRF1 Antibody |
| Product Description: | Goat Polyclonal anti-UHRF1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-LNQLFPGYGNGR, representing the C Terminus of the human protein according to NP_001041666.1; NP_037414.3 |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:1,000. Western Blot: Approx 85-90kDa band observed in lysates of cell lines Daudi and Jurkat (calculated MW of 89.8kDa according to NP_001041666.1 and 91.9kDa according to NP_037414.3). Recommended concentration: 0.03-0.1ug/ml. |
| Control: | Daudi cell lysate |
| Background: | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-UHRF1 antibody, anti-ubiquitin-like antibody, anti-containing PHD and RING finger domains antibody, anti-1 antibody, anti-Np95 antibody, anti-ICBP90 antibody, anti-FLJ21925 antibody, anti-transcription factor ICBP90 antibody, anti-RNF106 antibody, anti-MGC138707 antibody, anti-RING finger protein 106 antibody, anti-inverted CCAAT box-binding protein of 90 kDa antibody, anti-nuclear zinc finger protein Np95 antibody, anti-transcription factor ICBP90 antibody |
| ProteinTarget: | ICBP90 / UHRF1 |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse |
| GeneralRef: | Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C. ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression.Cancer Res. 2000 Jan 1;60(1):121-8.PMID: 10646863 |
| Gene_Id: | 29128 |
| Gene_Symbol: | UHRF1 |
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