| CatalogCode: | NB100-524 |
| ProductName: | NOD2 Antibody |
| Product Description: | Mouse Monoclonal anti-NOD2 (2D9) |
| Clone: | 2D9 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant human NOD2 protein corresponding to residues 28-301. |
| Specificity: | This antibody is specific for NOD2 protein. |
| CrossReactivity: | This antibody reacts with human protein. Other species have not been tested. |
| Packaging: | 0.1 ml protein G purified Mouse ascites. |
| Uses: | This antibody has been tested for Western blot of NOD2 transfected 293T lysates and HT29 human colorectal adenocarcinoma lysates (endogenous detection has some background) where a band is seen at ~110 kDa. Other applications have not been tested. The investigator should determine the optimal working dilution for a specific application. |
| Localization: | Cytoplasmic |
| Background: | NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease. |
| ProductRef: | 1. Lala, S., et al. Crohn's disease and the NOD2 gene: a role for the paneth cells. Gastroenterology. 125(1) 47-57 (2003) 2. Ogura, Y., et al. Expression of NOD2 in paneth cells: a possible link to Crohn's ileitis. Gut. 52 1591-1597(2005) |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Tris-glycine buffer containing 150mM NaCl |
| ListPrice: | 285 |
| AppSummary: | IP, WB, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-NOD-2 antibody; anti-NOD 2 antibody; anti-CARD15 antibody; anti-Caspase recruitment domain protein 15 antibody; anti-IBD1 antibody; anti-Inflammatory Bowel disease protein 1 antibody |
| ProteinTarget: | NOD2 [ 2D9 ] Antibody |
| PackageSize: | 0.1 ml |