| CatalogCode: | NB100-502 |
| ProductName: | Fanconi anemia D2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Fanconi anemia D2 [Ser222] |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to the human FANCD2 sequence (residues 217-226), surrounding a phosphorylated serine (222). |
| Specificity: | This antibody is specific for the phosphorylated form of FANCD2. |
| CrossReactivity: | Human. |
| Packaging: | 0.2 ml Rabbit antisera. |
| Uses: | The investigator should determine the optimal working dilution for a specific application.1:400 for PD20 FANCD2 overexpressing cells, 1:100 for HeLa cells, and 1:200 for other cell types. |
| Localization: | Nuclear |
| Background: | Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein. |
| ProductRef: | 1. Taniguchi, T., et al. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell. 109(4): 459-472 (2002). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Host_Name: | Rabbit |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-FA4 antibody; anti-FACD antibody; anti-FAD antibody; anti-FAD2 antibody; anti-FANCD antibody; anti-FANCONI ANEMIA COMPLEMENTATION GROUP D antibody; anti-FANCONI PANCYTOPENIA TYPE 4 antibody; anti-phosphorylated FANCD2 antibody; anti-phosphospecific FANCD2 antibody; anti-phosphorylated Fanconi anemia antibody |
| ProteinTarget: | Fanconi anemia D2 (FANCD2), phosphorylated Ser 222 antibody |
| PackageSize: | 0.2 ml |
| Phosphorylated: | Ser222 |