| Catalog Code: | NB100-439SS |
| Product Type: | Primary Antibody |
| Product Name: | Separase Antibody |
| List Price: | 95 |
| Clonality: | Monoclonal |
| Gene ID: | 9700 |
| Host: | Mouse |
| Clone: | XJ11-1B12 |
| Isotype: | IgG1 kappa |
| Product Description: | Mouse Monoclonal anti-Separase (XJ11-1B12) **Sample Size** |
| Cross Reactivity: | NB 100-439 recognizes human separase protein. Other species have not been tested. |
| Species Summary: | Hu |
| Background: | Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the |
| Alternate Names: | anti-Caspase like protein ESPL1 antibody, anti-ESP1 antibody, anti-ESPL1 antibody, anti-Extra spindle poles like 1 antibody, anti-KIAA0165 antibody, anti-Separin antibody, anti-Similar to fission yeast cut1and gene antibody, anti-SSE antibody |
| Immunogen: | Maltose-Binding Protein fusion of a C-terminal fragment of human separase (residues 1866-1996). |
| Localization: | Nuclear and Centrosomal |
| Purity: | protein G purified |
| Packaging: | 0.025 ml protein G purified Mouse ascites. |
| Package Size: | 0.025 ml |
| Concentration: | 0.9 mg/ml |
| Uses: | This antibody is useful for Western Blot, where a band is seen at ~220 kDa (full-length form) and ~65 kDa (auto-processed form). |
| Application Summary: | WB |
| General References: | 1. Chestukhin, A., et al. Western blot screening for monoclonalantibodies against human separase. J. Immunol. Methods. 274:105-113, 2003. [Western blot, Human] 2. Chestukhin, A., et al. Processing,localization, and requirement of human separase for normal |