| CatalogCode: | NB100-41425 |
| ProductName: | APC Antibody |
| Product Description: | Rabbit Polyclonal anti-APC |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide mapping to a region between residue 75 and 125 of human adenomatosis polyposis coli using the numbering given in entry NP_000029.2 (GeneID 324). |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Western Blot - Not recommended., Immunoprecipitation - 2 to 5 mcg/mg lysate., Immunohistochemistry - Not tested., Immunocytochemistry - Not tested. |
| Background: | APC is a tumor suppressor that regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division, and associates with other proteins involved in cell attachment and signaling. It plays a critical role in several cellular processes. APC regulates beta-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| ListPrice: | 325 |
| AppSummary: | IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Adenomatous Polyposis Coli antibody, anti-APC antibody, anti-DP2 antibody, anti-DP2.5 antibody, anti-DP3 antibody, anti-FAP antibody, anti-FPC antibody, anti-GS antibody |
| ProteinTarget: | APC |
| PackageSize: | 0.1 mg |
| Gene_Id: | 324 |
| Omim_ID: | NB100-41426 |
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