| CatalogCode: | NB100-41389 |
| ProductName: | PAK1 Antibody |
| Product Description: | Goat Polyclonal anti-PAK1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, CNTEKQKKKPKMSDE, representing the internal region of the human protein according to NP_002567.3 |
| CrossReactivity: | Human, Mouse, Rat. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:4,000. Western Blot: Approx 70kDa band observed in Human, Mouse and Rat Brain lysates (calculated MW of 60.6kDa according to NP_002567.3). Recommended concentration: 1-3ug/ml. |
| Control: | Rat Brain lysate |
| Background: | PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-PAK1 antibody, anti-p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog antibody, anti-yeast) antibody, anti-MGC130000 antibody, anti-MGC130001 antibody, anti-PAKalpha antibody, anti-p21-activated kinase 1 antibody, anti-p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) antibody |
| ProteinTarget: | PAK1 |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb;9(2):234-42. Epub 2006 Jan 15. PMID: 16415866 |
| NotesMain: | GeneID: 5058;18479 (mouse); 29431 (rat); No cross-reactivity exptected with PAK3 |
| Gene_Id: | 5058 |
| Omim_ID: | H00005058-A01 |
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