| CatalogCode: | NB100-41106 |
| ProductName: | CILP Antibody |
| Product Description: | Goat Polyclonal anti-CILP |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, NYRRTDHEDPRVK, representing the internal region of the human protein according to NP_003604.2 |
| CrossReactivity: | Tested: Rat Expected from sequence similarity: Human, Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx 150kDa band observed in Rat Spinal Cord lysates (calculated MW of 133kDa according to Human NP_003604.2 and of 132kDa according to Rat NP_001101631.1). Recommended concentration: 0.1-0.3ug/ml. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Rt |
| ALTnames: | anti-CILP antibody, anti-cartilage intermediate layer protein antibody, anti-nucleotide pyrophosphohydrolase antibody, anti-HGNC:1980 antibody, anti-HsT18872 antibody, anti-cartilage intermediate layer protein antibody |
| ProteinTarget: | CILP |
| PackageSize: | 0.1 mg |
| GeneralRef: | Seki S, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, Mio F, Mori M, Miyamoto Y, Masuda I, Tsunoda T, Kamata M, Kubo T, Toyama Y, Kimura T, Nakamura Y, Ikegawa S. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet. 2005 Jun;37(6):607-12. Epub 2005 May 1. PMID: 15864306 |
| NotesMain: | Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase. |
| Gene_Id: | 8483 |
| Omim_ID: | H00008483-A01 |
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