| CatalogCode: | NB100-41097 |
| ProductName: | GRIN2B Antibody |
| Product Description: | Goat Polyclonal anti-GRIN2B |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, KDAHEKDDFHHLS, representing the internal region of the human protein according to NP_000825.1 |
| CrossReactivity: | Rat. Other species not tested. Expected based upon sequence homology: Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Approx 170kDa band observed in Rat Brain lysates (calculated MW of 166kDa according to NP_000825.1). Recommended concentration: 2-4ug/ml. |
| Control: | Rat Brain lysate |
| Background: | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Rt |
| ALTnames: | anti-GRIN2B antibody, anti-glutamate receptor antibody, anti-ionotropic antibody, anti-N-methyl D-aspartate 2B antibody, anti-HGNC:4586 antibody, anti-NMDAR2B antibody, anti-NR2B antibody, anti-hNR3 antibody, anti-N-methyl-D-aspartate receptor subunit 2B antibody |
| ProteinTarget: | GRIN2B |
| PackageSize: | 0.1 mg |
| GeneralRef: | Arning L, Kraus PH, Valentin S, Saft C, Andrich J, Epplen JT. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17. PMID: 15742215 |
| Gene_Id: | 2904 |
| Omim_ID: | H00002905-B01 |