| CatalogCode: | | NB100-40809 |
| ProductName: | | PRNP Antibody |
| Product Description: | | Goat Polyclonal anti-PRNP |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide, C-SDYEDRYYREN, representing the internal region of the human protein according to NP_000302.1; NP_898902.1 |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | Peptide ELISA: antibody detection limit dilution 1:64,000. Western Blot: Approx 25kDa band observed in Human Brain lysates (calculated MW of 27.7kDa according to NP_000302.1 and NP_898902.1). Recommended concentration: 0.3-1ug/ml. |
| Control: | | Human Brain lysate |
| Background: | | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-PRNP antibody, anti-prion protein (p27-30) (Creutzfeldt-Jakob disease antibody, anti-Gerstmann-Strausler-Scheinker syndrome antibody, anti-fatal familial insomnia) antibody, anti-ASCR antibody, anti-CD230 antibody, anti-CJD antibody, anti-GSS antibody, anti-MGC26679 antibody, anti-PRIP antibody, anti-PrP antibody, anti-PrP27-30 antibody, anti-PrP33-35C antibody, anti-PrPc antibody, anti-CD230 antigen antibody, anti-major prion protein antibody, anti-prion protein antibody, anti-prion protein (p27-30) (Creutzfeld-Jakob disease Gerstmann-Strausler-Scheinker syndrome antibody, anti-fatal familial insomnia) antibody, anti-prion protein PrP antibody, anti-prion-related protein antibody |
| ProteinTarget: | | PRNP |
| PackageSize: | | 0.1 mg |
| Homology: | | Mouse, Rat, Dog, etc |
| GeneralRef: | | Ballerini C, Gourdain P, Bachy V, Blanchard N, Levavasseur E, Gregoire S, Fontes P, Aucouturier P, Hivroz C, Carnaud C. , Functional Implication of Cellular Prion Protein in Antigen-Driven Interactions between T Cells and Dendritic Cells. ,J Immunol. 2006 Jun 15;176(12):7254-62. , PMID: 16751368 |
| NotesMain: | | Gene ID = 5621 (human); 19122 (mouse); 24686 (rat); All variants represent the same protein. |
| Gene_Id: | | 5621 |
| Omim_ID: | | NB110-55663 |
| more information: | | company product webpage |
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