| CatalogCode: | | NB100-336 |
| ProductName: | | Ku70 Antibody |
| Product Description: | | Mouse Polyclonal anti-Ku70 |
| Clonality: | | Polyclonal |
| Immunogen: | | Recombinant protein encoding a C-terminal fragment of human Ku 70 expressed in E.coli. |
| Specificity: | | This antibody is specific for Ku70. |
| CrossReactivity: | | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | | 0.05 ml Whole antisera Mouse antisera. |
| Uses: | | Western Blotting: 1:2000 suggested dilution. Optimal working dilutions should be determined by the individual. |
| Localization: | | Nuclear |
| Control: | | HeLa or Raji whole cell or nuclear lysate. Recombinant human Ku 70 can also be used. |
| Background: | | Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Whole antisera |
| Isotype: | | IgG |
| Host_Name: | | Mouse |
| Buffer: | | n/a |
| ListPrice: | | 285 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-70 kDa subunit of Ku antigen antibody, anti-ATP dependent DNA helicase II 70 kDa subunit antibody, anti-CTC box binding factor 75 kDa subunit antibody, anti-CTC75 antibody, anti-Lupus Ku autoantigen protein p70 antibody, anti-ML8 antibody, anti-Ku 70 antibody |
| ProteinTarget: | | Ku70 |
| PackageSize: | | 0.05 ml |
| GeneralRef: | | General / background references:Jackson SP The recognition of DNA damage. Curr Opin Genet Dev 6:19-25 (1996). Weaver DT What to do at an end: DNA double-strand-break repair. Trends Genet 11:388-92 (1995). |
| more information: | | company product webpage |