| Catalog Code: | NB100-323 |
| Product Type: | Primary Antibody |
| Product Name: | ATR Antibody |
| List Price: | 275 |
| Clonality: | Polyclonal |
| Gene ID: | 545 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-ATR |
| Cross Reactivity: | NB 100-323 reacts with human and mouse. Other species have not been tested. The peptide used as the immunogen for this antibody shares 18 of 20 residues with Xenopus laevis. |
| Species Summary: | Hu, Mu |
| Background: | Ataxia and Rad3-related protein kinase (ATR) is a direct upstream activator of Chk1. This suggests that ATR plays a role in sensing DNA damage and initiating a subsequent protein kinase cascade. |
| Alternate Names: | anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1 antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATR antibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody, anti- |
| Immunogen: | A synthetic peptide, which represented a portion of human Ataxia and Rad3-related kinase encoded within exon 29 (LocusLink ID 545). |
| Specificity: | NB 100-323 is specific for human ATR protein. |
| Purity: | Affinity purified |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Uses: | NB 100-323 may be used for Western Blot. Suggested working dilutions: * Western Blot - 1:15,000-1:30,000 (ECL) Immunocytochemistry - Not DeterminedImmunoprecipitation - Not Determined |
| Application Summary: | WB |
| Product References: | Agarwal, C., Tyagi, A., and Agarwal, R. (2006) Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells, 5, 3294-3302. |
| Notes Main: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |