| Catalog Code: | NB100-322 |
| Product Type: | Primary Antibody |
| Product Name: | ATR Antibody |
| List Price: | 275 |
| Clonality: | Polyclonal |
| Gene ID: | 545 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-ATR |
| Cross Reactivity: | NB 100-322 reacts with human and mouse. Other species have not been tested. The peptide used as the immunogen for this antibody is not conserved in Xenopus laevis (18 out 20 amino acids). |
| Species Summary: | Hu, Mu |
| Background: | Ataxia and Rad3-related protein kinase (ATR) is a direct upstream activator of Chk1. This suggests that ATR plays a role in sensing DNA damage and initiating a subsequent protein kinase cascade. |
| Alternate Names: | anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1 antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATR antibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody, anti- |
| Immunogen: | A synthetic peptide, which represented a portion of human Ataxia and Rad3-related kinase encoded within exon 5 (LocusLink ID 545). |
| Localization: | Nuclear |
| Specificity: | NB 100-322 is specific for human ATR protein. |
| Purity: | Affinity purified |
| Buffer: | Tris-citrate/phosphate buffer pH 7-8 |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 1.0 mg/ml |
| Uses: | NB 100-322 may be used for Western Blot where the predicted MW is 317kDa.*The investigator should determine the optimal working dilution for a specific application. |
| Application Summary: | WB, ECL |
| Storage: | Store at 4C. Do not freeze. |
| Product References: | 1. Tyagi, A., Singh, R. P., Agarwal, C., and Agarwal, R. (2006) Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory l |
| Novus References: | Singh, R., et al. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. J. Nucl. Med. 2007 48(12): 2011-2020. |
| Notes Main: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |