| Catalog Code: | NB100-308 |
| Product Type: | Primary Antibody |
| Product Name: | ATR Antibody |
| List Price: | 285 |
| Clonality: | Monoclonal |
| Gene ID: | 545 |
| Host: | Mouse |
| Clone: | 2B5 |
| Isotype: | IgG |
| Product Description: | Mouse Monoclonal anti-ATR (2B5) |
| Cross Reactivity: | Human. Other species not yet tested. |
| Species Summary: | Hu |
| Background: | Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be in |
| Alternate Names: | anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1 antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATR antibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody, anti- |
| Immunogen: | A synthetic recombinant fragment, corresponding to amino acids 710-1100 of human ATR |
| Specificity: | NB 100-308 is specific for the human ATR. |
| Purity: | protein G purified |
| Buffer: | PBS |
| Packaging: | 0.1 ml protein G purified Mouse ascites. |
| Package Size: | 0.1 ml |
| Concentration: | 1 mg/ml |
| Uses: | Western blotting (a single~317 kDa band should be seen). Not tested in other applications. |
| Application Summary: | IF, IP, WB |
| General References: | 1. Bradbury JM & Jackson SP ATM and ATR. Curr Biol 13:R468 (2003). PubMed: 12814562 2. Abraham RT Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-96 (2001). PubMed: 11544175 |
| Product References: | 1. Post, S., et al. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage. PNAS. 98:13102-13107, 2001. 2. Horton, J.K., et al. Poly(ADP_ribose) polymerase ac |
| Novus References: | 1. Tyagi, Alpna, et al. Molecular Epidemiology and Cancer Prevention: Silivinin activates p53-caspase 2 pathway and causes caspasemediated cleavage of C ip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regula |