| Catalog Code: | NB100-307 |
| Product Type: | Primary Antibody |
| Product Name: | ATM kinase Antibody |
| List Price: | 275 |
| Clonality: | Monoclonal |
| Gene ID: | 472 |
| Host: | Mouse |
| Clone: | 10H11.E12 |
| Isotype: | IgG1 kappa |
| Product Description: | Mouse Monoclonal anti-ATM kinase (10H11.E12) [Ser1981] |
| Phosphorylated: | Ser1981 |
| Cross Reactivity: | NB 100-307 reacts with human ATM kinase. |
| Species Summary: | Hu |
| Background: | ATM-kinase plays an important regulatory role. DNA damage caused by such things as ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. |
| Alternate Names: | anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylated Ser 1981 antibody |
| Immunogen: | A synthetic peptide surrounding the phosphorylated serine at 1981. |
| Purity: | Ascites |
| Packaging: | 0.1 ml mouse ascites. |
| Package Size: | 0.1 ml |
| Uses: | This antibody is useful for Western blotting, where a single band is seen at ~370 kDa |
| Application Summary: | WB |
| General References: | 1. Bakkenist, C. et al. Nature. 421: 499-506 (2003)2. Bartek, J. et al. Nature. 421: 486-488 (2003) |
| Product References: | 1. Chu, P.C., et al. Silencing of p29 Affects DNA Damage Responses with UV Irradiation. Cancer Res. 66: 8484-8491 (2006) |
| Notes Main: | This antibody and certain aspects of its use are disclosed and claimed in pending U.S. Patent Applications published as U.S. Patent Publication Nos. 2003/0077661 and 2003/0157572. |