| Catalog Code: | NB100-306SS |
| Product Type: | Primary Antibody |
| Product Name: | ATM Kinase Antibody |
| List Price: | 95 |
| Clonality: | Monoclonal |
| Gene ID: | 5062 |
| Host: | Mouse |
| Clone: | 10H11.E12 |
| Isotype: | IgG1 Kappa |
| Product Description: | Mouse Monoclonal anti-ATM Kinase (10H11.E12) [Ser1981] **Sample Size** |
| Phosphorylated: | Ser1981 |
| Cross Reactivity: | NB 100-306 reacts with human and rat protein. |
| Species Summary: | Hu, Rt |
| Background: | ATM-kinase plays an important regulatory role. DNA damage caused by such things as ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. |
| Alternate Names: | anti-phosphorylated ATM antibody, anti-ATM S1981 antibody, anti-ATM phosphorylated Ser1981 antibody |
| Immunogen: | A synthetic peptide with a phosphorylated serine (1981). |
| Specificity: | NB 100-306 is specific for the human ATM kinase. |
| Purity: | Ascites |
| Packaging: | 0.025 ml Ascites Mouse ascites. |
| Package Size: | 0.025 ml |
| Uses: | Western blotting (a single~370 kDa band should be seen). Suggested working dilutions: * Western Blot - 1:1,000 (ECL) Immunoprecipitation - ND Immunocytochemistry - 1:1,000 *The investigator should determine the optimal working dilution for a specific appl |
| Application Summary: | WB |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | 1. Bakkenist, C. et al. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506, 2003. 2. Bartek, J. et al. DNA Repair: Damage Alert. Nature 421(6922): 486-488, 2003. 3. Mikailov, A. et al. DNA Damage |
| Notes Main: | This antibody and certain aspects of its use are disclosed and claimed in pending U.S. Patent Applications published as U.S. Patent Publication Nos. 2003/0077661 and 2003/0157572. |