| CatalogCode: | | NB100-2845 |
| ProductName: | | CDX2 Antibody |
| Product Description: | | Goat Polyclonal anti-CDX2 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide: EQLSPGGQRRNLCE, representing the internal region of the human protein according to NP_001256.1 |
| CrossReactivity: | | Reactivity based upon sequence homology: Human, Mouse, Rat, Dog |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | Peptide ELISA: antibody detection limit dilution 1:4,000. Approx 38kDa band observed in Human Kidney and Liver lysates (calculated MW of 33.5kDa according to NP_001256.1). The observed molecular weight corresponds to earlier findings in literature (Qualtrough et al Gut. 2002 Aug;51(2):184-90; PMID: 12117877). Recommended concentration: 1-3ug/ml. |
| Background: | | CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-CDX2 antibody, anti-caudal type homeo box transcription factor 2 antibody, anti-HGNC:1806 antibody, anti-CDX-3 antibody, anti-CDX3 antibody, Trophectoderm Marker |
| ProteinTarget: | | CDX2 |
| PackageSize: | | 0.1 mg |
| Homology: | | Mouse, Rat, Dog |
| GeneralRef: | | Wells JM, Melton DA. Vertebrate endoderm development. Annu Rev Cell Dev Biol. 1999;15:393-410. Review. PMID: 10611967 |
| NotesMain: | | No cross-reactivity expected with CDX1 and 4 |
| Gene_Id: | | 1045 |
| Omim_ID: | | H00001045-M01 |
| more information: | | company product webpage |