| CatalogCode: | NB100-2838 |
| ProductName: | STAM2 Antibody |
| Product Description: | Goat Polyclonal anti-STAM2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: C-QSIDPTDSKPDSQD, representing the internal region of the human protein according to NP_005834.3 |
| CrossReactivity: | Reactivity based upon sequence homology: Human, Mouse, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:8,000. Western Blot: Approx 70kDa band observed in Human Spleen lysates (calculated MW of 58.2kDa according to NP_005834.3). The observed molecular weight corresponds to earlier findings in literature (Pandey et al J Biol Chem. 2000 Dec 8;275(49):38633-9; PMID: 10993906). Recommended concentration: 1-3ug/ml. |
| Background: | The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-STAM2 antibody, anti-signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody, anti-HGNC:11358 antibody, anti-DKFZp564C047 antibody, anti-Hbp antibody, anti-STAM2A antibody, anti-STAM2B antibody, anti-STAM-like protein containing SH3 and ITAM domains 2 antibody, anti-signal transducing adaptor molecule 2 antibody |
| ProteinTarget: | STAM2 |
| PackageSize: | 0.1 mg |
| Homology: | Mouse, Dog |
| GeneralRef: | Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem. 2005 Mar 18;280(11):10468-77. Epub 2005 Jan 7. PMID: 15640163 |
| NotesMain: | No cross-reaction expected with STAM1. |
| Gene_Id: | 10254 |
| Omim_ID: | H00010254-A01 |
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