| CatalogCode: | NB100-2822 |
| ProductName: | TRAF1 Antibody |
| Product Description: | Goat Polyclonal anti-TRAF1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: C-KLQSPKHAYVKDD, representing the C Terminus of the human protein according to NP_005649.1 |
| CrossReactivity: | Human. Other species not tested. Reactivity based upon sequence homology: Mouse |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Approx 50-55kDa band observed in lysates of monocytic leukemia cell line U937 (calculated MW of 46.2kDa according to NP_005649.1). The observed molecular weight corresponds to earlier findings in literature (Pryhuber et al , Am J Respir Cell Mol Biol. 2000 Feb;22(2):150-6. PMID: 10657935). Recommended concentration: 0.3-1.0ug/ml. |
| Control: | U937 cell lysate |
| Background: | The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TRAF1 antibody, anti-TNF receptor-associated factor 1antibody, anti-EBI6 antibody, anti-MGC:10353antibody, anti-Epstein-Bar virus-induced protein 6 antibody |
| ProteinTarget: | TRAF1 |
| PackageSize: | 0.1 mg |
| Homology: | Mouse |
| GeneralRef: | Su X, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling. Eur J Immunol. 2006 Jan;36(1):199-206. PMID: 16323247 |
| Gene_Id: | 7185 |
| Omim_ID: | NB100-56171 |
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