| CatalogCode: | NB100-2816 |
| ProductName: | P27KIP1 Antibody |
| Product Description: | Goat Polyclonal anti-P27KIP1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-KRPATDDSSTQNK, representing the internal region of the human protein according to NP_004055.1 |
| CrossReactivity: | Human. Other species not tested.Expected reactivity based upon sequence homology: Dog, Cat |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000.
Western Blot: Approx 26kDa band observed in lysates of Human Prostate and of Hepatoblastoma cell line HepG2 (calculated MW of 22.1kDa according to NP_004055.1). The observed molecular weight corresponds to earlier findings in literature (Xia et al, Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33; PMID: 16169901). Recommended concentration: 0.1-0.3µg/ml. |
| Background: | Gene ID: 1027
NP_004055.1 |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CDKN1B antibody, anti-cyclin-dependent kinase inhibitor 1B (p27 antibody, anti-Kip1) antibody, anti-CDKN4 antibody, anti-KIP1 antibody, anti-P27KIP1 antibody, anti-cyclin-dependent kinase inhibitor 1B antibody |
| ProteinTarget: | P27KIP1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005 Jan;7(1):51-63. PMID: 15652749 |
| NotesMain: | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. |
| Gene_Id: | 1027 |
| Omim_ID: | NB100-78265 |
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