| CatalogCode: | NB100-2811 |
| ProductName: | GLI3 Antibody |
| Product Description: | Goat Polyclonal anti-GLI3 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-HNKRSKIKPDED, representing the internal region of the human protein according to NP_000159.2 |
| CrossReactivity: | Expected reactivity based upon sequence homology: Human, Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:16,000.<br>Western Blot: Preliminary experiments in Human Brain, Lung, Placenta and Testes lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? |
| Background: | Gene ID: 2737
NP_000159.2 |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 195 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-GLI3 antibody, anti-GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) antibody, anti-ACLS antibody, anti-GCPS antibody, anti-PAP-A antibody, anti-PAPA antibody, anti-PAPA1 antibody, anti-PAPB antibody, anti-PHS antibody, anti-PPDIV antibody, anti-DNA-binding protein antibody, anti-GLI-Kruppel family member GLI3 antibody, anti-oncogene GLI3 antibody, anti-zinc finger protein GLI3 antibody |
| ProteinTarget: | GLI3 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK. Gli2 and gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 2005 Oct;1(4):e53. Epub 2005 Oct 28. PMID: 16254602 |
| NotesMain: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. |
| Gene_Id: | 2737 |
| Omim_ID: | H00002737-A01 |
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