| CatalogCode: | NB100-277 |
| ProductName: | NBS1 Antibody |
| Product Description: | Rabbit Polyclonal anti-NBS1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide, which represented a portion of human Nijimegen breakage syndrome 1 between amino acid residues 625 and 675 encoded in part by exons 12 and 13 (LocusLink ID 4683). |
| Specificity: | This antibody is specific for human NBS1. |
| CrossReactivity: | NB 100-277 recognizes human NBS1. Other species have not been tested. Reactivity with mouse and rat is unlikely owing to divergence from sequence of the peptide used for immunization. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody can be used in western blot, where a band is seen around 100 kDa, and immunoprecipitation. |
| Localization: | Nuclear |
| Background: | The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. |
| ProductRef: | Heffernan et al., J.Biol.Chem 282 (13):9458-9468, 2007. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| ListPrice: | 285 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | AT V1 antibody, AT V2 antibody, ATV antibody, Cell cycle regulatory protein p95 antibody, FLJ10155 antibody, MGC87362 antibody, NBN antibody, NBS 1 antibody, NBS antibody, NBS1 antibody, Nibrin antibody, Nijmegen breakage syndrome antibody, Nijmegen breakage syndrome protein 1 antibody, p95 antibody |
| ProteinTarget: | Nbs1 |
| PackageSize: | 0.1 ml |
| NotesMain: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |