| CatalogCode: | NB100-2734 |
| ProductName: | Cytokeratin 16 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 16 (LL025) |
| Clone: | LL025 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide (Human). |
| Specificity: | This antibody reacts with the 48 kD human cytokeratin intermediate filament protein identified as CK16. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.5 ml |
| Uses: | This antibody can be used on formalin-fixed, paraffin-embedded and frozen tissue sections at a dilution of 1:20 to 1:40 and an incubation of 1 hour at room temperature . When using routinely processed tissues, heat mediated antigen retrieval is strongly recommended. For western blotting use at 1:50 The optimal conditions should be determined by the individual laboratory. |
| Localization: | CK16 is expressed in the cytoplasm. |
| Control: | Any non-melanocytic skin cancer or basal cell carcinoma. |
| Background: | Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomas |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgM |
| Host_Name: | Mouse |
| Buffer: | 20 mM tris-borate, 150 mM sodium chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine se |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IHC-P, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | Cytokeratin 16 |
| PackageSize: | 0.5 ml |
| GeneralRef: | General / background references:Markey AC et al. Keratin expression in basal cell carcinomas. Br J Dermatol 126:154-60 (1992). Wetzels RH et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol 138:751-63 (1991). |
| NotesMain: | Prolonged fixation in buffered formalin can destroy the epitope. |
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