| CatalogCode: | NB100-2688 |
| ProductName: | MCSP Antibody |
| Product Description: | Mouse Monoclonal anti-MCSP (LHM 2) |
| Clone: | LHM 2 |
| Clonality: | Monoclonal |
| Immunogen: | Tissue / cell preparation (Human - a 375P cell crude extract). |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.25 mg |
| Uses: | FACS: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 240 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | Preservative: NoneConstituents: PBS |
| ListPrice: | 295 |
| AppSummary: | FACS, IHC-Fr, IHC-P, IP, WB |
| ProteinTarget: | MCSP |
| PackageSize: | 0.25 mg |
| GeneralRef: | This clone has been used in:Kupsch JM et al. Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells. Clin Cancer Res 5:925-31 (1999). Kupsch JM et al. Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens. Melanoma Res 5:403-11 (1995). |
| NotesMain: | The LHM2 antibody is a very good marker for melanoma (>90% stained). LHM2 also stains basal cell carcinomas and subpopulation of basal keratinocytes. LHM2 can be used as a diagnostic panel for immunopathology of malignant melanoma and potential candidates for immunoimaging and immunotherapy of disseminated melanoma. The originators of this antibody report that the MCSP is a cell surface marker specific for epidermal stem cells (J. Invest. Dermatol. in press). Potential applications of the LHM2 antibody include use for separation/isolation of epidermal stem cells, detection of stem cells in skin biopsies or epithelial cell cultures and optimisation of culture conditions to retain epidermal stem cell population in in vitro cultures. |
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