| CatalogCode: | NB100-2683 |
| ProductName: | L1CAM Antibody |
| Product Description: | Mouse Monoclonal anti-L1CAM (UJ181.4) |
| Clone: | UJ181.4 |
| Clonality: | Monoclonal |
| Immunogen: | Tissue / cell preparation. 16 week human foetal brain. |
| Specificity: | Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 136 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS |
| ListPrice: | 295 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-antigen identified by monoclonal R1 antibody, anti-CD171 antibody, anti-HGNC:7086 antibody, anti-HSAS1 antibody, anti-L1 cell adhesion molecule antibody, anti-MASA antibody, anti-MIC5 antibody, anti-N CAML1 antibody, anti-NEURAL CELL ADHESION MOLECULE L1 PRECURSOR antibody, anti-S10 antibody, anti-SPG1 antibody |
| ProteinTarget: | L1CAM |
| PackageSize: | 0.1 mg |
| GeneralRef: | This clone has been used in:Bourne S et al. Monoclonal antibodies M340 and UJ181.4 recognize antigens associated with primitive neuroectodermal tumours/tissues. Hybridoma 8:415-26 (1989). General / background references:Kemshead JT et al. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells. Int J Cancer 31:187-95 (1983). |
| NotesMain: | UJ181.4 can be used in diagnosis of primitive neuroectodermal tumours. It can be used for bone marrow purging and intrathecal targeting. |