| CatalogCode: | | NB100-2682 |
| ProductName: | | L1CAM Antibody |
| Product Description: | | Mouse Monoclonal anti-L1CAM (UJ127.11) |
| Clone: | | UJ127.11 |
| Clonality: | | Monoclonal |
| Immunogen: | | Tissue preparation: Homogenous suspension of 16 week human foetal brain |
| Specificity: | | UJ127.11 may be useful in the diagnosis of embryonic tumours (e.g. neuroblastoma). |
| CrossReactivity: | | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg IgG purified Mouse ascites. |
| Uses: | | IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 140 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Cell Membrane |
| Background: | | The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | IgG purified |
| Isotype: | | IgG1 |
| Host_Name: | | Mouse |
| Buffer: | | PBS |
| ListPrice: | | 295 |
| AppSummary: | | IP, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-antigen identified by monoclonal R1 antibody, anti-CD171 antibody, anti-HGNC:7086 antibody, anti-HSAS1 antibody, anti-L1 cell adhesion molecule antibody, anti-MASA antibody, anti-MIC5 antibody, anti-N CAML1 antibody, anti-NEURAL CELL ADHESION MOLECULE L1 PRECURSOR antibody, anti-S10 antibody, anti-SPG1 antibody |
| ProteinTarget: | | L1CAM |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | This product has been used in:Patel K et al. Monoclonal antibody UJ127.11 recognizes the human homologue of mouse L1 cell adhesion molecule. Biochem Soc Trans 18:274 (1990). Kemshead JT et al. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells. Int J Cancer 31:187-95 (1983). |
| more information: | | company product webpage |