| CatalogCode: | NB100-2523 |
| ProductName: | SIRT6 Antibody |
| Product Description: | Rabbit Polyclonal anti-SIRT6 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350). [Swiss-Prot Q8N6T7] |
| CrossReactivity: | Human. Other species have not been tested. The immunogen used for the production of this antibody shows 78% homology with the mouse protein and 71% homology with the rat protein. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis, where a band is seen at ~39 kDa. A higher MW band ~59 kDa may be seen with lower dilutions (ie: 2 ug/ml).Investigator should determine optimal working conditions and dilutions. |
| Localization: | Nuclear |
| Background: | Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human ageing. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate (pH 7-8) |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Mono-ADP-ribosyltransferase sirtuin-6 antibody; anti-SIR2-like protein 6 antibody; anti-Silent information regulator 2-like protein 6 antibody |
| ProteinTarget: | SIRT6 |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Michishita, E., et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Bio. Cell. 16: 4623-4635 (2005) |
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