| CatalogCode: | NB100-2521 |
| ProductName: | Speedy / Ringo Antibody |
| Product Description: | Rabbit Polyclonal anti-Speedy / Ringo |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to a C-terminal region of the human Speedy protein (within residues 200-286). This immunogen is conserved in both isoforms 1 and 2. [Swiss-Prot Q5MJ69] |
| Specificity: | This antibody is specific for Speedy/Ringo protein. |
| CrossReactivity: | Mouse. Other species have not been tested. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis, where a band is seen at ~36 kDa (isoform 2). After a longer exposure, a 31 kDa band can be detected (isoform 1). There is also a non-specific band at ~58 kDa. This antibody was tested against human and mouse brain samples, but failed to detect proteins of the predicted size in either lysate. |
| Localization: | Nuclear |
| Control: | Mouse testis lysate |
| Background: | Speedy/Ringo (Spy1) regulates the G1/S phase transition of the cell cycle by binding and activating CDC2, CDK2 and CDKN1B/KIP1. It mediates cell survival during the DNA damage process through activation of CDK2. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate (pH 7-8) |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Speedy A isoform antibody; anti-SPDY1 protein antibody; anti-Spy antibody; anti-Ringo antibody; anti-Spy1 antibody |
| ProteinTarget: | Speedy/Ringo |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Porter, LA., Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. JCB. 157(3): 357-366 (2002) |
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