| CatalogCode: | NB100-2519 |
| ProductName: | Crystallin AB Antibody |
| Product Description: | Rabbit Polyclonal anti-Crystallin AB |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to an internal region of the human Crystallin AB protein (within residues 100-175). [Swiss-Prot P02511] |
| Specificity: | This antibody is specific for crystallin AB protein. |
| CrossReactivity: | Human and mouse. Other species have not been tested. The immunogen used for the production of this antibody has 100% homology with mouse, rat, sheep, rabbit, monkey, hamster, cow, chicken, and pig proteins and 81% homology with Zebrafish protein. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis, where a band is seen at ~20 kDa. There is also a band of greater intensity at ~40 kDa that may be an aggregated heteromeric complex. Investigator should determine optimal working conditions and dilutions.**CryAB aggregates with homologous proteins, including CryAA and the small heat shock protein HSP28, to form large heteromeric complexes. |
| Localization: | Cytoplasmic |
| Control: | Human and mouse skeletal muscle lysate |
| Background: | Crystallin AB (CryAB) is a developmentally regulated small heat shock protein known to protect cells from stress damage. It may also play an important role in the Golgi reorganization during cell division. CryAB is known to be associated with a number of neurodegenerative pathologies such as Alzheimer disease amd multiple sclerosis. As well, it has been found to be expressed in breast tumors of patients with shorter survival, suggesting that it may be a useful marker in identifying aggressive breast cancer. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate (pH 7-8) |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Alpha crystallin B chain antibody; anti-CryAB antibody; anti-Alpha (B)-crystallin antibody; anti-Rosenthal fiber componet antibody; anti-Heat-shock protein beta-5 antibody; anti-HspB5 antibody; anti-CryA2 antibody; anti-AACRYA antibody; anti-Alpha crystallin B chain antibody; anti-CRYA2 antibody; anti-Crystallin alpha polypeptide 2 antibody; anti-CTPP 2 antibody; anti-CTPP2 antibody; anti-Heat shock 20 kD like protein antibody; anti-Heat shock protein beta 5 antibody; anti-HSPB5 antibody; anti-Rosenthal fiber component antibody |
| ProteinTarget: | Crystallin AB |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Gangalum, RK., et al. JCB. 279(42): 43374-43377 (2004) 2. Sanbe, A., et al. PNAS. 102(38): 13592-13597 (2005) 3. Liu, H., et al. JCB. 280(26): 25071-25078 (2005) |
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