| CatalogCode: | NB100-2463 |
| ProductName: | WWOX Antibody |
| Product Description: | Goat Polyclonal anti-WWOX |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: C-TEEKTQWEHPKTGK, representing the internal region of the human protein according to NP_057457.1; NP_570607.1 |
| Specificity: | This antibody is expected to recognise isf 1 (NP_057457.1) and isf 2 (NP_570607.1). |
| CrossReactivity: | Expected reactivity based upon sequence homology: Human, Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:64,000.
Western Blot: Preliminary experiments in lysates of Human Ovary, Prostate and Testes gave no specific signal but low background (at antibody concentration up to 1ug/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? |
| Background: | Gene ID(s): 51741 (human) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | 195 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-WWOX antibody, anti-WW domain containing oxidoreductaseantibody, anti-HGNC:12799 antibody, anti-D16S432E antibody, anti-FOR antibody, anti-FRA16D antibody, anti-HHCMA56 antibody, anti-PRO0128 antibody, anti-WWOX v8antibody, anti-FOR II protein antibody, anti-WW domain-containing oxidoreductase antibody, anti-WW domain-containing protein WWOX antibody, anti-fragile 16D oxido reductase antibody, anti-fragile site FRA16D oxidoreductase antibody, anti-putative oxidoreductase antibody |
| ProteinTarget: | WWOX |
| PackageSize: | 0.1 mg |
| GeneralRef: | Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 13; [Epub ahead of print] PMID: 16223882
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| NotesMain: | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. |
| Gene_Id: | 51741 |
| Omim_ID: | H00051741-B01 |
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