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| Catalog Code: | NB100-2307 |
| Product Name: | WASP Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-WASP [Ser484] |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 7454 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody isphosphorylated Serine 483, phosphorylated Serine 484 and surrounding residues of human Wiskott-Aldrich syndrome using the numbering given in entry NP_000368.1 (GeneID 7454). |
| Cross Reactivity: | Human. Reactivity with Mouse WASP phosphorylated at the residues corresponding to S483 and S484 of Human WASP is likely owing to conservation of sequence between Human and Mouse WASP in the vicinity of these residues. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use. Suggested starting dilutions are as follows.Western Blot: 1:1,000 |
| Background: | The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-WAS antibody, anti-WASP antibody, anti-Wiskott-Aldrich Syndrome (eczema-thrombocytopenia) Protein antibody, anti-THC antibody, anti-Thrombocytopenia 1 (X-linked) antibody, anti-IMD2 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Phosphorylated: | Ser484 |
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