| CatalogCode: | NB100-2261 |
| ProductName: | UBE1C Antibody |
| Product Description: | Rabbit Polyclonal anti-UBE1C |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized by NB 100-2261 maps to a region between residue 400 and the C-terminus (residue 463) of human Ubiquitin-activating Enzyme E1C using the numbering given in entry NP_003959.3 (GeneID 9039). |
| CrossReactivity: | Human. Other species have not been tested. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use.Suggested starting dilutions are as follows:*Western Blot: 1:1,000 to 1:5,000Immunoprecipitation: 3 to 10 mcg/mg lysateImmunohistochemistry: not testedImmunocytochemistry: not tested*Investigator should determine optimal working conditions and dilutions. |
| Background: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| ListPrice: | 295 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-UBE1C antibody, anti-Ubiquitin-activating Enzyme E1C antibody, anti-UBA3 antibody, anti-hUba3 antibody, anti-Human homolog of yeast UBA3 antibody |
| ProteinTarget: | UBE1C |
| PackageSize: | 0.1 ml |
| Gene_Id: | 9039 |
| Omim_ID: | H00079876-B01 |
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