| request information: |
|
| Catalog Code: | NB100-2230 |
| Product Name: | SIRT2 Antibody |
| Product Description: | Rabbit Polyclonal anti-SIRT2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 22933 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 1 and 50 of human sirtuin (silent mating type information regulator 2 homolog) 2 using the numbering given in entry NP_036369.2 (GeneID 22933). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use.Suggested starting dilutions are as follows:*Western Blot: 1:1,000. For endogenouse Sirt2, nocodazole treatment and IP is required before blotting.Immunoprecipitation: 2 to 5 mcg/mg lysateImmunohistochemistry: not testedImmunocytochemistry: not tested*Investigator should determine optimal working conditions and dilutions. |
| Background: | The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | Western Blot, immunoprecipitation |
| Species Summary: | Hu |
| Alternate Names: | anti-Sirt2 antibody, anti-Sirt-2 antibody, anti-Sir2L antibody, anti-Sir2L2 antibody, anti-Sirtuin (silent mating type information regulation 2 homolog) 2 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
order or
more information: | company product webpage |