| CatalogCode: | NB100-2185 |
| ProductName: | IL-10 Antibody |
| Product Description: | Mouse Monoclonal anti-IL-10 (3C12C12) |
| Clone: | 3C12C12 |
| Clonality: | Monoclonal |
| Immunogen: | Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3). |
| CrossReactivity: | Human. Other species have not been tested |
| Packaging: | 0.1 mg of purified ascites |
| Uses: | Anti- IL-10 recognizes recombinant human IL-10 by Western Blot and ELISA. |
| Localization: | Secreted |
| Background: | Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CSIF antibody; Anti-Cytokine Synthesis Inhibitory Factor antibody; Anti-IL 10 antibody; Anti-IL10A antibody; Anti-Interleukin 10 antibody; Anti-Interleukin10 antibody; Anti-MGC126450 antibody; Anti-MGC126451 antibody; Anti-TGIF antibody |
| ProteinTarget: | IL-10 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1.Vieira P, et al. PNAS, 1991.88:1172-1176 |