| CatalogCode: | NB100-2183 |
| ProductName: | IFN-gamma Antibody |
| Product Description: | Mouse Monoclonal anti-IFN-gamma (3F1E3) |
| Clone: | 3F1E3 |
| Clonality: | Monoclonal |
| Immunogen: | Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3) |
| CrossReactivity: | Human. Other species have not been tested. |
| Packaging: | 0.1 mg of purified ascites. |
| Uses: | Anti- IFN-gamma recognizes recombinant IFN-gamma by Western Blot and ELISA. Dilution: Western Blot: 1:500-1,000 ELISA: Determining optimal working dilutions by titration test. |
| Background: | Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| ListPrice: | 295 |
| AppSummary: | WB, ELISA |
| SpeciesSummary: | Hu |
| ProteinTarget: | IFN-gamma |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Takayanagi, H. et al. Nature 2000. 408: 600-605. 2. Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999. |