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| Catalog Code: | NB100-2135 |
| Product Name: | hnRNP-U Antibody |
| Product Description: | Rabbit Polyclonal anti-hnRNP-U |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 3192 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 775 and the C-terminus (residue 824) of human Heterogeneous Nuclear Ribonucleoprotein U using the numbering given in entry NP_114032.1 (GeneID 3192). |
| Cross Reactivity: | Human and Mouse. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined experimentally by the investigator. Prepare workingdilution immediately before use. Suggested starting dilutions are as follows:Western Blot: 1:1,000-1:5,000Immunoprecipitation: 2 to 5 mcg/mg lysate.Immunohistochemistry: not testedImmunocytochemistry: not tested |
| Background: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | Western Blot, immunoprecipitation |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-hnRNPU antibody, anti-hnRNP-U antibody, anti-heterogeneous nuclear ribonucleoprotein U antibody, anti-SAF-A antibody, anti-scaffold attachment factor A antibody, anti-p120 nuclear prote |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |