| CatalogCode: | NB100-1973 |
| ProductName: | Cu/Zn SOD Antibody |
| Product Description: | Rabbit Polyclonal anti-Cu/Zn SOD |
| Clonality: | Polyclonal |
| Immunogen: | Full length protein (Rat). |
| CrossReactivity: | Cross-reacts with Human, Mouse, Rat, Xenopus laevis, Cow, Dog, Hamster, Monkey, Pig, Rabbit and Sheep. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | ELISA: Use at an assay dependent dilution. IHC: Use at a concentration of 1 ug/ml. IP: Use at a concentration of 10 ug/ml. WB: Use at a concentration of 1 ug/ml. Detects a band of approximately 19 and 23 kDa (predicted molecular weight: 18 kDa). Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin binding multimer of disulfide linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase(CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50% Glycerol, 0.1M Sodium Phosphate. pH 7.0 |
| ListPrice: | 295 |
| AppSummary: | ELISA, IHC, IP, WB |
| SpeciesSummary: | Bv, Ca, Ha, Hu, Mu, Mk, Rt, Rb, Sh, Xp |
| ALTnames: | anti-ALS 1 antibody, anti-ALS antibody, anti-ALS1 antibody, anti-Amyotrophic lateral sclerosis 1 antibody, anti-Homodimer antibody, anti-IPOA antibody, anti-SOD 1 antibody, anti-SOD antibody, anti-SOD1 antibody, anti-Soluble indophenoloxidase A antibody, anti-Superoxide dismutase 1 antibody, anti-Superoxide dismutase 1 soluble antibody, anti-Superoxide dismutase Cu Zn antibody |
| ProteinTarget: | Cu/Zn Superoxide Dismutase |
| PackageSize: | 0.05 mg |
| GeneralRef: | Kurobe N et al. Sensitive enzyme immunoassay for human Cu/Zn superoxide dismutase. Clin Chim Acta 187:11-20 (1990). Kurobe N et al. Sensitive enzyme immunoassay for human Mn superoxide dismutase. Clin Chim Acta 192:171-9 (1990). Wong GH et al. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58:923-31 (1989). |
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