| Catalog Code: | NB100-1951 |
| Product Type: | Primary Antibody |
| Product Name: | Drebrin Antibody |
| List Price: | 275 |
| Clonality: | Monoclonal |
| Gene ID: | 1627 |
| Host: | Mouse |
| Clone: | M2F6 |
| Isotype: | IgG |
| Product Description: | Mouse Monoclonal anti-Drebrin (M2F6) |
| Cross Reactivity: | Cross-reacts with Human, Mouse, Rat, Cat, Chicken and Guinea pig. Not yet tested in other species. |
| Species Summary: | Ch, Hu, Mu, Rt, Fe |
| Background: | Drebrins are actin-binding proteins, that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single debrin gene in the chicken brain. The ex |
| Alternate Names: | anti-D0S117E antibody, anti-DBN 1 antibody, anti-DBN1 antibody, anti-Developmentally regulated brain protein antibody, anti-DKFZp434D064 antibody, anti-Drebrin 1 antibody, anti-Drebrin E antibody, anti-Drebrin1 antibody, DrebrinE antibody |
| Immunogen: | Chicken Drebrin E protein. |
| Localization: | Cytoplasmic |
| Specificity: | This antibody detects Drebrin A and E in samples from human, mouse, rat, guinea pig, and cat origins and Drebrin E only in chicken samples. |
| Purity: | protein A purified |
| Buffer: | PBS with 10mg/ml Sucrose [pH 7.2] |
| Packaging: | 0.05 mg protein A purified Mouse ascites. |
| Package Size: | 0.05 mg |
| Concentration: | 1 mg/ml |
| Uses: | In Western Blot a 110kDa band is seen due to large amounts of negative residues (predicted MW 65kDa). Heat treatment is required for paraffinembedded tissue. Microwave 2x10 min in citrate buffer, pH 6.5. Optimal dilutions should be determined by the end u |
| Application Summary: | IHC, WB |
| General References: | 1. Shirao, T. and Obata, K. (1986) Brain Res. 394, 233-244. 2. Imamura, K., et al. (1992) Neurosci Res. 13, 33-41. 3. Kojima, N., et al. (1988) Brain Res. 464, 207-215. 4. Shirao, T. (1995) J Biochem. 117, 231-236.5. Peitsch, W.K., et al. (1999) Eur J Cel |
| Product References: | 1. Maezawa, I., Nivison, M., Montine, K. S., Maeda, N., and Montine, T. J. (2006) Neurotoxicity from innate immune response is greatest with targeted replacement of ε4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK, 05-5 |
| Notes Main: | For maximum product recovery, after thawing, centrifuge the product vial before removing cap. |
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