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| Catalog Code: | NB100-1868 |
| Product Name: | Caspase 14 Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase 14 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | A 15 residue synthetic peptide derived from N terminal domain of Human Caspase 14. |
| Specificity: | This antibody reacts with Caspase 14 in cell extracts. |
| Cross Reactivity: | Reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit Ascites |
| Uses: | This antibody can be used in Western Blot and immunohistochemistry.*Optimal dilutions should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Caspases are a family of cysteine proteases that play key roles in apoptosis. The precursor form of all caspaes is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunits, which associate into a2b2 tetramers to form the active enzyme. Caspase 14 also known as Mini ICE (MICE) is a member of the peptidase family C14 that has three potential isoforms. The pro form of Caspase 14 is approximately 29 kD. This caspase may be involved in the death receptor and granzyme B apoptotic pathways. Caspase 14 functions as downstream signal transducer of cell death that can be suppressed by retinoic acid. Caspase 14 becomes activated after granzyme B, Caspase 8, and Caspase 10 cleavage into large p18 and small p10 subunits. This caspase has been shown to associate with the large prodomain caspases, including Caspase 1, Caspase 2, Caspase 4, Caspase 8, and Caspase 10. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have a role in ontogenesis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry 1/100-1/500, Western Blot 1/500-1/5000 |
| Species Summary: | Hu |
| Alternate Names: | anti-Apoptosis related cysteine protease antibody, anti-CASP 14 antibody, anti-CASP14 antibody, anti-Caspase 14 apoptosis related cysteine protease antibody, anti-Caspase 14 precursor antibody, anti-Caspase14 antibody, anti-MGC119078 antibody, anti-MGC119079 antibody, anti-MICE antibody, anti-Mini ICE antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
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more information: | company product webpage |