| CatalogCode: | NB100-1854 |
| ProductName: | OSP Antibody |
| Product Description: | Rabbit Polyclonal anti-OSP |
| Clonality: | Polyclonal |
| Immunogen: | A 15 residue synthetic C-terminal peptide. |
| Specificity: | Reacts specifically with 74 kDa protein derived from CNS samples. |
| CrossReactivity: | Cross-reacts with Rat. Not yet tested in other species. |
| Packaging: | 0.2 ml Whole Rabbit antisera. |
| Uses: | Optimal dilutions should be determined by the end user. |
| Background: | Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. |
| ProductRef: | Hellani A et al. Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. Endocrinology 141:3012-9 (2000). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Whole Serum |
| ListPrice: | 325 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Rt |
| ALTnames: | anti-Claudin 11 antibody, anti-CLDN11 antibody, anti-Oligodendrocyte transmembrane protein antibody, anti-OSP antibody, anti-OTM antibody |
| ProteinTarget: | OSP |
| PackageSize: | 0.2 ml |
| NotesMain: | Lyophilized-reconstitute with 200 ul distilled water. |
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