| CatalogCode: | NB100-1837 |
| ProductName: | VGLUT1 Antibody |
| Product Description: | Rabbit Polyclonal anti-VGLUT1 |
| Clonality: | Polyclonal |
| Immunogen: | A 17 residue synthetic peptide derived from C-terminal domain of rat VGLUT1. |
| Specificity: | No cross reactivity has been detected with VGLUT2 and VGLUT3. |
| CrossReactivity: | Cross-reacts with Human and Rat. Not yet tested in other species. |
| Packaging: | 0.025 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody can be used in Electron Microscopy, Immunohistochemistry, and Western Blot. In Western Blot a 60 kDa band is seen.*Optimal dilutions should be determined by the end user. |
| Localization: | Cell Membrane |
| Control: | Rat brain lysate. |
| Background: | VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 0.1M Tris with 0.1MGlycine and 50% Glycerol [pH7.8] |
| ListPrice: | 325 |
| AppSummary: | IHC, WB, EM |
| SpeciesSummary: | Hu, Rt |
| ALTnames: | anti-NAPI1 antibody, anti-NPT1 antibody, anti-SLC17A1 antibody, anti-Sodium dependent inorganic phosphate cotransporter antibody, anti-Solute carrier family 17 (sodium phosphate) member 1 antibody, anti-Vesicular glutamate transporter 1 antibody |
| ProteinTarget: | VGLUT1 |
| PackageSize: | 0.025 mg |
| GeneralRef: | Herzog E et al. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci 21:RC181 (2001). |
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